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Woman Who Underwent The World’s First Face Transplant Dies Aged 49

(FILES) - Combo of pictures (dated, at L 06 February 2006, at R from November 2006) of French Isabelle Dinoire, 39, a few months after her surgery operation carried out jointly by an Amiens and Lyon team who underwent the world's first facial face transplant, and a year later. When Isabelle Dinoire received the transplant, doctors warned she might never be able to kiss again. Now the 40-year-old French woman can eat, speak and smile normally, according to "Isabelle's Kiss," a book on her odyssey released this week. Mixing narrative and interviews with Dinoire, the book takes the reader from the day the young woman was rushed to hospital in May 2005 after being disfigured by her dog, to the press conference the following February at which she revealed her new face to the world. AFP PHOTO DENIS CHARLET (L) AFP PHOTO-CENTRE HOSPITALIER UNIVERSITAIRE AMIENRS (CHU AMIENS) (R) (Photo credit should read DENIS CHARLET/AFP/Getty Images)

The Frenchwoman with  the world’s first face transplant has died almost eleven years since the ground breaking  operation. Isabelle Dinoire, 49, succumbed to two types of cancer earlier this summer after a decade taking powerful immunosuppressant drugs. The drugs were designed to prevent her body rejecting new tissues, but they always threatened to make Ms Dinoire seriously ill.

Miss Dinoire, from Valenciennes, northern France, got attention of the world in November 2005 when she was given a new nose, mouth and chin at the nearby Amiens Hospital.

Mandatory Credit: Photo by REX/Shutterstock (572995o) Isabelle Dinoire before the surgery FACE TRANSPLANT PATIENT ISABELLE DINOIRE AT A PRESS CONFERENCE, AMIENS, FRANCE - 06 FEB 2006

[Isabelle Dinoire before the surgery [06 FEB 2006]  Credit: Photo by REX/Shutterstock]

It took a team led by Professor Bernard Duvauchelle, an oral and maxillofacial surgeon, 15 hours to perform the medical breakthrough. A triangle of face tissue from a brain-dead woman’s nose and mouth were grafted onto Miss Dinoire.

Three years on, Miss Dinoire admitted that she remained uncertain as to whose face she looked at in the mirror every day.

Issabel

(Photo credit DENIS CHARLET/AFP/Getty Images)

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